Areas of interest to the Boggon lab are briefly described.
Cerebral Cavernous Malformations
Cerebral Cavernous Malformations (CCM)
Normal regulation of signal transduction by the CCM proteins is lost in CCM disease. This is associated with formation of mulberry-shaped blood vessels in the brain or spine, which can have major complications [see the Angioma Alliance website]. Some of the major changes in signaling are alterations in Rho cascades. We have determined the first crystal structures that describe each of the three CCM proteins and are using structure-directed functional approach to discover their roles and importance in signal transduction.