laboratory
Jun 17, 2020
New paper in : JBC "The GTPase-activating protein p120RasGAP has an evolutionarily conserved “FLVR-unique” SH2 domain." by Jaber Chehayeb R, Wang J, Stiegler AL and Boggon TJ.
Jun 12, 2020
New book chapter in : Methods in Molecular Biology "Crystallographic Studies of the Cerebral Cavernous Malformations Proteins." by Fisher OS, Li X, Liu W, Zhang R and Boggon TJ.
Apr 11, 2020
Max Paul joins the lab - Welcome Max!
Mar 12, 2020
Kimberly Vish joins the lab - Welcome Kimmie!
Dec 31, 2019
New paper in : PLOS ONE "Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide." by Jaber Chehayeb R, Stiegler AL and Boggon TJ.
Nov 5, 2019
Congratulations to Gaby for passing her Qualifying Exam!
Jun 5, 2019
Preview in Structure: "Clamping together hemidesmosomes and latching them in place."
Apr 10, 2019
News and Views in Nature Chemical Biology: "ARGuing for a new kinase class."
Mar 28, 2019
Gabriela Casanova joins the lab - Welcome Gaby!
Dec 6, 2018
New paper in : Biochemical Society Transactions "PseudoGTPase domains in p190RhoGAP proteins: a mini-review." by Stiegler AL and Boggon TJ
Nov 6, 2018
Amy's paper in Structure is a "Featured Article"
Aug 30, 2018
New paper in : Structure "The N-terminal GTPase domain of p190RhoGAP proteins is a pseudoGTPase" by Stiegler AL and Boggon TJ
Jan 2, 2018
New paper in : PNAS "CDC42 binds PAK4 via an extended GTPase-effector interface" by Ha BH and Boggon TJ
Dec 6, 2017
New paper in : JBC "The crystal structure of pseudokinase PEAK1 (Sugen Kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization" by Ha BH and Boggon TJ
Dec 1, 2017
New paper in : Scientific Reports "The repeat region of cortactin is intrinsically disordered in solution" by Li X, et al.,
Oct 11, 2017
New paper in : Biochim Biophys Acta "PAK4 crystal structures suggest unusual kinase conformational movements" by Zhang EY, Ha BH and Boggon TJ
Sep 11, 2017
New paper in : Nature Communications "p190RhoGAP proteins contain pseudoGTPase domains" by Stiegler AL and Boggon TJ
May 5, 2016
New paper in : Molecular Cell "Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases" by Hamill S, Lou HJ, Turk BE and Boggon TJ
Mar 1, 2016
Xiaofeng leaves for a new position - Good luck Xiaofeng!
Oct 14, 2015
New paper in : Journal of Structural Biology "Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD–FERM interface" by Zhang R, Li X, Boggon TJ
Aug 3, 2015
New paper in : Nature Communications "Structure and vascular function of a MEKK3-cerebral cavernous malformations 2 complex" by Fisher OS, Deng H, Liu D et al.
Jun 19, 2015
Oriana leaves for a Postdoc at NorthWestern - Good luck Oriana!
Apr 27, 2015
Eric receives a Yale College Dean's Research Fellowship - Congratulations Eric!
Apr 8, 2015
New paper in : JBC "Signaling, regulation and specificity of the type II p21-activated kinases" by Ha BH et al.
Mar 30, 2015
New paper in : JCB "CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation" by Draheim KM, Li X, et al.
Mar 30, 2015
New paper in : Acta Cryst F "Crystal structure of ABL2/ARG kinase in complex with Dasatinib" by Ha BH, et al.
Feb 24, 2015
Oriana successfully defends - Congratulations Dr. Fisher!
Dec 17, 2014
New paper in : JBC "Structural basis for the disruption of the Cerebral Cavernous Malformations 2 (CCM2) interaction with Krev Interaction Trapped 1 (KRIT1) by disease-associated mutations" by Fisher OS, et al.
Jul 24, 2014
New paper in : JBC "Structural determinants for binding of Sorting Nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev Interaction Trapped 1 (KRIT1)" by Stiegler AL, et al.
Jun 2, 2014
New paper in : JBC "Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin." by Gifford SM*, Liu W* et al.
May 1, 2014
Welcome to Zhijun Zhang!
Jan 30, 2014
New 'At a Glance' review and poster in : Journal of Cell Science "Cerebral cavernous malformation proteins at a glance." by Draheim KM, Fisher OS, Boggon TJ and Calderwood DA.
Dec 26, 2013
New paper in : Molecular Cell "Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity." by Chen C*, Ha BH* et al.
Nov 29, 2013
New review in : Cellular and Molecular Life Sciences "Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology." by Fisher OS and Boggon TJ
Sep 5, 2013
New paper in : PLOS ONE "Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6." by Gao J, et al.
Sep 1, 2013
Jia leaves for an Assistant Professorship at the Chinese Academy of Agricultural Sciences, Beijing - Good luck Jia!
Jul 23, 2013
Oriana wins a Pauling Poster Prize at the ACA annual meeting. Congratulations Oriana!
Apr 27, 2013
New paper in : Acta Cryst F "Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide." by Liu W, Boggon TJ
Crystals featured on the Hampton Research website.
Mar 18, 2013
New paper in : Protein and Peptide Letters "SHP family protein tyrosine phosphatases adopt canonical active-site conformations in the apo and phosphate-bound states." by Alicea-Velazquez NL, Boggon TJ
Jan 31, 2013
New paper in : PLOS ONE "Purification and SAXS analysis of the Integrin Linked Kinase, PINCH, parvin (IPP) heterotrimeric complex." by Stiegler AL, Grant TD, Luft JR, Calderwood DA, Snell EH, Boggon TJ.
Jan 10, 2013
New paper in : Molecular Cell "Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation." by Liu W., Draheim KM, Zhang R, Calderwood DA, Boggon TJ.
Jan 2, 2013
New paper in : PNAS "RAC1-P29S is a spontaneously activating cancer-associated GTPase." by Davis MJ, Ha BH, Holman EC, Halaban R, Schlessinger J, Boggon TJ.
Dec 26, 2012
New paper in : FEBS Letters "Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus." by Fisher OS, Zhang R, Li X, Murphy JW, Demeler B, Boggon TJ.
Sep 28, 2012
Weizhi leaves to start his own lab at the Ocean University of China, Qingdao - Good luck Weizhi!
Sep 17, 2012
New paper in : PNAS "Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate." by Ha BH et al.
Sep 10, 2012
Nilda passes her pre-defense - Congratulations Nilda!
Aug 6, 2012
New paper in : JBC "Structural basis for paxillin binding and focal adhesion targeting of β-parvin" by Stiegler AL, Draheim KM, Li X, Chayen NE, Calderwood DA, Boggon TJ.
Aug 1, 2012
Nilda wins a Pauling Poster Prize at the ACA annual meeting. Congratulations Nilda!
July 29, 2012
New paper in : Nature Genetics "Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma." by Krauthammer M et al. Press release Science editors choice USNews Newsday Sky News HeraldSun Telegraph Yahoo! HealthCanal TVNZ NBC14 ABC7 CBS3 FOX54
May 10, 2012
New paper in : JBC "Structural basis for the small G-protein-effector interaction of Ras-related protein 1 (Rap1) and the adaptor protein Krev interaction trapped 1 (KRIT1)" by Li X, Zhang R, Draheim KM, Liu W, Calderwood DA, Boggon TJ.
Apr 3, 2012
New paper in : JBC "Calcium-induced conformational changes in the C-terminal tail of polycystin-2 are necessary for channel gating." by Celic AS, Petri ET, Benbow J, Hodsdon ME, Ehrlich BE, Boggon TJ.
Jan 29, 2012
New paper in : Acta Cryst Section F "Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex." by Liu W, MacGrath SM, Koleske AJ, Boggon TJ.
July 16, 2011
Mention in the New Haven Register.
June 9, 2011
News from the Women's Health Research at Yale program.
May 25, 2011
Xiaofeng accepts an American Heart Association Founders Affiliate Postdoctoral Fellowship. Congratulations Xiaofeng!
May 1, 2011
Welcome to Stephanie Hamill!
Mar 15, 2011
Oriana passes her qualifying exam. Congratulations Oriana!
Apr 1, 2011
New paper in : Current Drug Targets "The use of structural biology in Janus kinase targeted drug discovery." by Alicea-Velazquez NL, Boggon TJ.
July 31, 2010
Ed accepts a faculty position at the University of Novi Sad, Serbia. Congratulations Ed!
July 14, 2010
Oriana accepts an NSF Graduate Research Fellowship. Congratulations Oriana!
June 21, 2010
Welcome to Oriana Fisher!
May 15, 2010
Welcome to Weizhi Liu!
May 11, 2010
New paper in JBC : "Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity." by Li X*, Zhang R*, Zhang H, He Y, Ji W, Min W, Boggon TJ.
May 4, 2010
New paper in PNAS : "Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity." by Petri ET, Celic AS, Kennedy SD, Ehrlich BE, Boggon TJ, Hodsdon ME.
Mar 23, 2010
Welcome to Byung Hak Ha!